Introduction & Programme
The second annual Oxford RNAi conference, RNAi2007, covered a diverse variety of topics in the field, including advances in understanding biology of RNA interference and its potential applications in gene function analysis and therapy. The conference brought together a diverse mix of participants, including leading experts from both academia and industry, postdoctoral researchers, graduate students and managers. It provided an excellent opportunity to discover the latest research directions and thinking in this fast moving field in academic and commercial settings as well as to develop new collaborative links.
Day 1, 29 March 2007
Session I: Chaired byDr Mark Lindsay
8.30 am Dr Javier Martinez, Austria
The biology behind post-transcriptional regulation of microRNA expression
9.00 am Dr Jan Weiler, Novartis, Switzerland
microRNAs in biomedical research
9.30 am Dr Carsten Alsbo , Exiqon, Denmark
Probing non-coding RNA
Session II: Chaired by Dr Dmitry Samarsky
10.45 am Dr Erik Miska, Cambridge, UK
MicroRNAs in C. elegans development and human disease
11.15 am Dr Wigard Kloosterman , Utrecht, The Netherlands
MicroRNAs in animal development
11.45 am Dr Alla Grishok, Cambridge, USA
The nuclear aspect of RNAi in C. elegans
12.15 am Dr Mark Lindsay, London, UK
miRNAs and inflammation
Session III: Chaired by Dr Erik Miska
2.00 pm Adam Bostanci, The British Library, UK
On the launch of UKPMC
2.10 pm Dr Volker Patzel, Berlin, Germany
siRNA: Structure-based design and prokaryotic gene silencing
2.40 pm Dr Andrei Thomas-Tikhonenko, Pennsylvania, USA
Myc-regulated microRNAs: Friends and foes
3.10 pm Dr Dmitry Samarsky, Dharmacon/Thermofisher, USA
3.40 pm Dr Dmitry Samarsky, Dharmacon/Thermofisher, USA
High-throughput RNAi screening: Initial steps toward creation of a functional map of the human genome
Session IV: Chaired by Professor Georg Sczakiel
4.30 pm Dr Ludger Altrogge, amaxa, Germany
Delivery of RNAi reagents using Nucleofector 96-well Shuttle System - from single gene analysis to screening applications
5.00 pm Dr Tod Woolf, RXi Pharmaceuticals, USA
Delivery of intact RNAi to target tissues in vivo
5.30 pm Dr Stacy Deeds, Sigma-Aldrich, USA
A lentiviral vector-based RNAi library screen to identify genes that modulate cellular response to paclitaxel
Day 2, 30 March 2007
Session V: Chaired by Professor John Rossi
8.30 am Dr Jens Kurreck, Berlin, Germany
Evolution of gene silencing technologies: Antisense oligonucleotides, siRNAs and shRNAs for target validation in pain research
9.00 am Prof Ben Berkhout, Amsterdam, The Netherlands
Antiviral RNAi approaches
9.30 am Dr Dong-Yan Jin, Hong Kong, China
Interactions between the human double-stranded RNA binding proteins, TRBP, PACT, and Dicer to facilitate the production of siRNA
10.00 am Prof James Uney, Bristol, UK
Novel proteins involved in RNAi: Are Scaffold attachment factor proteins involved in RNAi?
Session VI: Chaired by Professor Ben Berkhout
11.00 am Dr Joel Neilson, Cambridge, USA
Short RNA expression in T lymphocyte development
11.30 am Keynote Prof John Rossi, The City of Hope, Duarte, California, USA
RNAi and HIV infection
12.30 pm Dr Petr Svoboda, Basal, Switzerland
Defining roles for RNA silencing in mammalian cells
Session VII: Chaired by Dr Tod Woolf
2.10 pm Prof Georg Sczakiel, Germany
Intracellular trafficking and localisation of siRNA is a bottle-neck for its biological activity
2.40 pm Dr Martin Fabani, Cambridge, UK
Inhibition of microRNAs by synthetic oligonucleotide analogs
3.10 pm Dr Ines Royaux, Johnson & Johnson, Belgium
Highly-efficient delivery of RNA interference to peripheral neurons
in vivo using Herpes Simplex Virus
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