Programme


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	12 March 2008 4.00pm - 8.00pm Arrival and registration of resident delegates ----------------------------------------------------------- 13 March 2008 8.00am Registration 8.50am Welcome *Session I: Chair Dr Mike Gait* 9.00am Dr James Parker, Oxford, UK Title: Argonaute proteins and RNA silencing 9.30am Professor Denise Barlow , Vienna, Austria Title: Control of imprinted expression by the Air macro ncRNA 10.00am Professor Barbara Demeneix, Paris, France Title: Comparing non-viral methods for siRNA and shRNA delivery to the mouse neural stem cell niche 10.30am Refreshment Break, Exhibitions, Posters *Session II: Chair Professor Barbara Demeneix* 11.00am Dr René Ketting (KEYNOTE SPEAKER), Utrecht, The Netherlands Title: Small RNAs in germline development 11.50am Dr Deborah Bourc'his, Paris, France Title: Functional links between DNA methylation, retrotransposon suppression and repeat-associated small RNA biogenesis in the mammalian germ line 12.20pm Dr Rehan Ali (short presentation), Oxford, UK Title: SephaCe - A tool for accurate segmentation of biological cells from brightfield microscopy 12.40pm Lunch Break, Exhibitions, Posters *Session III: Chair Dr Georg Sczakiel* 2.00pm Professor Jørgen Kjems, Aarhus, Denmark Title: Optimization of siRNA function, in vivo delivery and therapeutic potential by chemical modifications and polymeric formulation 2.30pm Dr Justin Teissie, Toulouse, France Title: In vivo electro-delivery of RNA silencing reagents 3.00pm Dr Dmitry Samarsky, RXi Phrama, USA Title: Development of a novel RNAi therapeutic program 3.30pm Dr Roger Kaspar, TransDerm Inc, Santa Cruz, CA, USA Title: Refined animal models for optimising delivery of functional siRNAs to skin 4.00pm Refreshment Break, Exhibitions, Posters *Session IV: Chair Dr Dmitry Samarsky* 4.30pm Professor Georg Sczakiel, Lübeck, Germany Title: Increased RNAi is related to intracellular release of siRNA after phosphorothioate-stimulated cellular delivery: Sub-cellular localization and biological efficacy 5.00pm Professor Andrei Thomas-Tikhonenko, Philadelphia, USA Title: Repression of the miR-15a/16 tumor suppressor gene by the Pax5 transcription factor: Implications for B-lymphomagenesis 5.30pm Dr Gwen Fewell, Open Biosystems, USA Title: An inducible genome-wide human lentiviral shRNAmir library for mammalian RNAi 6.00pm Dr Ian Sudbery (short presentation), Cambridge, UK Title: Enrichment of hexamer and heptamer ‘seed’ sequences in siRNAs scoring highly in a functional screen 6.15pm Close of day 1 6.30pm Drinks Reception (Sponsored by Integrated DNA Technologies) 7.15pm Dinner (by invitation only) ------------------------------------- 14 March 2008 *Session V: Chair Dr Matthew Wood* 8.45am Dr Thomas Thum, Würzburg, Germany Title: MicroRNAs in cardiovascular disease - mechanisms and therapeutic approaches 9.15am Dr Renee Schroeder, Austria Title: Molecular basis for target RNA recognition and cleavage by human RISC 9.45am Dr David Horn, London, UK Title: Analysis of gene function in trypanosomes 10.15am Refreshment Break, Exhibitions, Posters 10.45am Poster and Exhibition Viewing 11.45am Professor Esther Stoeckli, Zurich, Switzerland Title: RNAi opens new possibilities for functional gene analysis during development of the vertebrate nervous system 12.15pm Dr Adam Baker, Exiqon, Vedbæk, Denmark Title: Global microRNA profiling using novel LNA miRCURY microarrays enables identification of tumors of unknown primary origin. The development of microRNA based diagnostics 12.45pm Lunch Break, Exhibition, Posters *Session VI: Chair Dr Gwen Fewell* 2.15pm Dr Chris Lord, London, UK Title: RNAi in target identification and validation 2.45pm Dr Ludger Altrogge, amaxa 3.15pm Dr Stephanie Urschel , Thermofisher/Dharmacon, USA Title: Development of an integrated platform for genome-wide RNAi screening 3.45pm Dr Matthew Wood, Oxford, UK Title: Gene silencing for neurodegenerative disease 4.15pm Close of conference and Refreshments	Introduction & Scope Programme Posters Call for Sponsors Registration & Fees Accommodation Getting to Oxford General Information Contacts Sponsors Gold Silver Drinks Reception
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