Mini-Review J Mol Genet Med (August 2005), 1(1), 11-17 doi: jmgm Published online: 03 August 2005 Full Text: (html | pdf ~1500kb | refs) Significance of the Y-box proteins in human cancers Ken Matsumoto † and Boon-Huat Bay ‡* † Laboratory of Cellular Biochemistry, RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan *Correspondence to: Boon-Huat Bay, Email: antbaybh@nus.edu.sg, Tel: +65 68746139, Fax: +65 67787643 Received: 24 June 2005, Revised: 01 August 2005, Accepted: Accepted 01 August © Copyright The Authors ----------------------------------------------------------------------------------------------------------------- ABSTRACT Y-box proteins belong to the cold shock domain family of proteins that are known to be involved in both transcriptional and translational control. Here, we give a brief overview of the structure, regulation and physiological functions of the Y-box proteins. This is followed by examining the role of Y-box protein 1 (YB-1), the most extensively studied of the Y-box protein in tumorigenesis, and its clinicopathological significance. YB-1 has the potential to be a prognostic marker and predictor of chemoresistance in human cancers. KEYWORDS: YB-1, structure and regulation, tumorigenesis, clinicopathological significance, prognostication, chemoresistance ----------------------------------------------------------------------------------------------------------------- Privacy | Disclaimer |